Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine.
Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine.
复制标题
普拉克索可减轻心室内 6-羟基多巴胺引起的多巴胺能细胞损失。
DOI：
10.1007/s007020050014
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Carvey,PM
中科院分区：
文献类型：
--
作者：
Vu,TQ;Ling,ZD;Ma,SY;Robie,HC;Tong,CW;Chen,EY;Lipton,JW;Carvey,PM
d3偏好多巴胺激动剂普拉克索已被证明可以减轻左旋多巴诱导的体外细胞损失。本文在6-羟多巴胺损伤模型中评估普拉克索，以确定其体内作用。大鼠在脑室内注射6-羟多巴胺前后分别给予丙哌索或生理盐水。在初步研究中，6-羟多巴胺导致纹状体多巴胺减少68%，黑质中酪氨酸羟化酶免疫反应（THir）细胞计数减少62%。服用普拉克索的动物纹状体多巴胺和th3细胞数量分别减少了29%和27%。细胞计数与纹状体多巴胺显著相关。在体视学研究中，6-羟多巴胺使生理盐水处理动物的thr细胞计数减少47%，普拉克索处理动物的thr细胞计数减少26%。这些数据表明，普拉克索能减弱6-羟多巴胺通常产生的生化和THir细胞变化，这与普拉克索在体外的神经保护作用一致。
The D3preferring dopamine agonist pramipexole has been shown to attenuate the cell loss induced by levodopa in vitro. Pramipexole was herein evaluated in the 6-hydroxydopamine lesion model to determine its in vivo effect. Rats were treated with pramipexole or saline before and after an intracerebroventricular 6-hydroxydopamine injection. In the preliminary study, 6-hydroxydopamine produced a 68% reduction in striatal dopamine and a 62% loss in tyrosine hydroxylase immunoreactive (THir) cell counts in the substantia nigra. Pramipexole treated animals exhibited a 29% and a 27% reduction in striatal dopamine and THir cell counts, respectively. THir cell counts and striatal dopamine were significantly correlated. In the stereological study, 6-hydroxydopamine reduced THir cell counts by 47% in saline treated animals and 26% in pramipexole treated animals. These data demonstrate that pramipexole attenuates the biochemical and THir cell changes normally produced by 6-hydroxydopamine consistent with its neuroprotective actions in vitro.