Effects of eye position on saccades evoked electrically from superior colliculus of alert cats.
Effects of eye position on saccades evoked electrically from superior colliculus of alert cats.
复制标题
眼睛位置对警觉猫上丘电诱发眼跳的影响。
DOI：
10.1152/jn.1986.55.1.97
复制
发表时间：
1986
影响因子：
2.5
通讯作者：
McIlwain,JT
中科院分区：
文献类型：
--
作者：
McIlwain,JT
在警觉猫的上级丘的中间和深灰色层进行电刺激。将动物头部固定，用巩膜探测线圈法记录其眼球运动。长时间脉冲串刺激前三分之二的丘会产生多次扫视，就像灵长类动物一样（45，51），但它们的方向和幅度受到眼睛初始位置的显著影响。刺激后半部分的丘引起的扫视，似乎是“目标导向”，而刺激的最尾部边缘的丘产生中心扫视。这些观察结果证实了Roucoux和Crommelinck（48）以及Guitton等人（24）先前的报告。在双侧同时刺激上级丘诱发的扫视也依赖于眼睛的初始位置。在一定的相对强度的刺激两侧，扫视未能发生时，眼睛是在一个特定的部分的视范围。当眼睛在这个区域之外时，同样的刺激触发了眼球运动，将眼睛推向眼跳失败的区域。这些研究结果表明，扫视命令所造成的局灶性丘刺激猫可以修改的信息，当前的眼睛位置。不确定这在大脑中的何处发生或通过什么神经机制发生，但是扫视控制系统（46）的局部反馈模型可以解释主要观察。这些发现的功能意义在很大程度上取决于局灶性丘刺激再现自然发生的神经活动模式的程度。
Electrical stimulation was carried out in the intermediate and deep gray layers of the superior colliculus in alert cats. The heads of the animals were fixed, and their eye movements were recorded with the scleral search coil method. Stimulation in the anterior two-thirds of the colliculus with long-duration pulse trains produced multiple saccades, as in the primate (45, 51), but their directions and amplitudes were influenced significantly by the initial position of the eye. Stimulation in the posterior part of the colliculus evoked saccades that appeared to be "goal-directed," whereas stimulation at the extreme caudal edge of the colliculus yielded centering saccades. These observations confirm previous reports of Roucoux and Crommelinck (48) and Guitton et al. (24). Saccades evoked during bilateral simultaneous stimulation of the superior colliculi were also dependent on the initial position of the eye. At certain relative intensities of stimulation on the two sides, saccades failed to occur when the eye was within a particular part of the oculomotor range. When the eye was outside this region, the same stimuli triggered an eye movement that drove the eye toward the zone of saccade failure. These findings indicate that saccadic commands resulting from focal collicular stimulation in the cat can be modified by information about current eye position. It is not certain where in the brain this occurs or by what neural mechanisms, but a local feedback model of the saccadic control system (46) can account for the main observations. The functional significance of these findings depends in large measure on the degree to which focal collicular stimulation reproduces naturally occurring patterns of neural activity.