Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits
Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits
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DOI：
10.1038/11330
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发表时间：
1999-08-01
期刊：
影响因子：
82.9
通讯作者：
Soltesz, I
中科院分区：
文献类型：
--
作者：
Chen, K;Baram, TZ;Soltesz, I
发热（发热引起的）惊厥影响3-5%的婴儿和幼儿。尽管热性惊厥的发病率很高，但其对以后癫痫发展的贡献仍然存在争议。结合一种新的大鼠模型的复杂的热性惊厥和膜片钳技术，我们确定，高血压诱导的癫痫发作在未成年大鼠引起选择性突触前增加抑制性突触传递的海马，持续到成年。热性惊厥后突触通讯的这些强有力的改变的持久性质不支持早期热性惊厥的“良性”性质的流行观点。
Febrile (fever-induced) seizures affect 3-5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial. Combining a new rat model of complex febrile seizures and patch clamp techniques, we determined that hyperthermia-induced seizures in the immature rat cause a selective presynaptic increase in inhibitory synaptic transmission in the hippocampus that lasts into adulthood. The long-lasting nature of these potent alterations in synaptic communication after febrile seizures does not support the prevalent view of the 'benign' nature of early-life febrile convulsions.