Toward imaging biomarkers for osteoarthritis
Toward imaging biomarkers for osteoarthritis
复制标题
DOI：
10.1097/01.blo.0000144972.50849.d9
复制
发表时间：
2004-10-01
影响因子：
4.2
通讯作者：
Sorensen, AG
中科院分区：
文献类型：
--
作者：
Gray, ML;Eckstein, F;Sorensen, AG
许多新的治疗策略已经和正在开发，以纠正，预防或减缓骨关节炎的进展。我们评估这些技术的有效性，或确定它们可能提供最大益处的情况的能力，关键取决于可以作为软骨当前或预测状态的代理的诊断措施。在过去的几十年中出现的许多磁共振成像技术似乎很有前途，因为它们在测量软骨的形态和分子状态方面显示出技术有效性。随着持续的发展和试点临床研究的增加，这些或相关的方法可能很快就会被习惯使用。这些技术是范式转变的一部分，治疗策略与诊断方法携手发展，这一转变有望加速有效疗法的发展，并将其集中在最成功的领域。
Many new therapeutic strategies have been and are being developed to correct, prevent, or slow the progression of osteoarthritis. Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies for the present or predicted state of the cartilage. Many of the magnetic resonance imaging techniques that have been emerging over the past decades appear promising in that they have shown technical validity in measuring the morphologic and molecular state of cartilage. With continued development and added insight from pilot clinical studies, these or related methods may soon be in customary use. These techniques are part of a paradigm shift where therapeutic strategies are developed hand-in-hand with diagnostic approaches-a shift that offers the promise of speeding development of effective therapies, and focusing their use in areas where they can be most successful.