Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity
Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity
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DOI：
10.1007/s11011-006-9012-7
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发表时间：
2006-09-01
影响因子：
3.6
通讯作者：
Daya, S.
中科院分区：
文献类型：
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作者：
Maharaj, H.;Maharaj, D. S.;Daya, S.
由于氧化应激在神经退行性疾病中的影响，我们决定单独或组合研究乙酰水杨酸和对乙酰氨基酚的抗氧化特性。使用硫代巴比妥酸测定 (TBA) 和硝基蓝四唑 (NBT) 测定来研究喹啉酸 (QA) 诱导的大鼠海马体内脂质过氧化和超氧阴离子生成。该研究还表明，使用甲酚紫染色，在 QA 损伤的大鼠海马体中用乙酰水杨酸和对乙酰氨基酚治疗后，神经元细胞的结构完整性得以保留。此外，该研究还试图确定这些药物是否对内源性 (QA) 的形成有影响。这项研究表明，乙酰水杨酸和对乙酰氨基酚可抑制 QA 诱导的大鼠海马体内超氧阴离子生成、脂质过氧化和细胞损伤。此外，这些药物还能抑制负责合成内源性 QA 的酶 3-羟基邻氨基苯甲酸加氧酶 (3-HAO)。
Due to the implication of oxidative stress in neurodegenerative disorders we decided to investigate the antioxidant properties of acetylsalicylic acid and acetaminophen either alone or in combination. The thiobarbituric acid assay (TBA) and the nitroblue tetrazolium (NBT) assay were used to investigate quinolinic acid (QA)-induced: lipid peroxidation and superoxide anion generation in the rat hippocampus, in vivo. The study also shows, using cresyl violet staining, the preservation of structural integrity of neuronal cells following treatment with acetylsalicylic acid and acetaminophen in QA-lesioned rat hippocampus. Furthermore the study sought to determine whether these agents have any effect on endogenous (QA) formation. This study shows that acetylsalicylic acid and acetaminophen inhibit QA-induced superoxide anion generation, lipid peroxidation and cell damage, in vivo, in the rat hippocampus. In addition these agents inhibit the enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO), responsible for the synthesis of endogenous QA.