Porphyromonas gingivalis: major periodontopathic pathogen overview.

Porphyromonas gingivalis: major periodontopathic pathogen overview.
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DOI:
10.1155/2014/476068
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发表时间:
2014
影响因子:
4.1
通讯作者:
Duskova J
Duskova J
中科院分区:
医学3区
文献类型:
--
作者:
Mysak J;Podzimek S;Sommerova P;Lyuya-Mi Y;Bartova J;Janatova T;Prochazkova J;Duskova J

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牙龈卟啉单胞菌是一种革兰氏阴性口腔厌氧菌,参与牙周炎的发病机制,是生活在口腔中的 500 多种细菌的一员。这种厌氧细菌是口腔微生物组的天然成员,但它可以变得具有高度破坏性(称为致病菌)并在牙周病变中增殖到大量细胞:这归因于其专门的毒力因子库。本综述的目的是概述主要的牙周病原体之一——牙龈卟啉单胞菌。这种细菌与齿垢密螺旋体和连翘坦纳菌一起构成了“红色复合体”,这是牙周炎中多菌致病菌群的原型。这篇综述概述了牙龈卟啉单胞菌的结构、其代谢、其定植上皮细胞的能力及其对宿主免疫的影响。
Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens—Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the “red complex,” a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.
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