Protein phosphorylation and the nuclear organization of pre-mRNA splicing
Protein phosphorylation and the nuclear organization of pre-mRNA splicing
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DOI：
10.1016/s0962-8924(96)20043-1
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发表时间：
1997-04-01
影响因子：
19
通讯作者：
Spector, DL
中科院分区：
文献类型：
--
作者：
Misteli, T;Spector, DL
转录和前mRNA剪接的受控执行对于正确的基因表达是至关重要的。这些基本事件在细胞核内的组织才刚刚开始被理解。在这里，我们描述了一个基于最近的生化和形态数据的转录和前mRNA剪接的细胞排列模型：转录和前mRNA剪接在空间和时间上是协调的，蛋白质磷酸化调节Se活性和前mRNA剪接因子在核亚室中的亚核定位。
Controlled execution of transcription and pre-mRNA splicing is crucial for proper gene expression. The organization of these essential events within the cell nucleus is only beginning to be understood. Here, we describe a model for the cellular arrangement of transcription and pre-mRNA splicing based on recent biochemical and morphological data: transcription and pre-mRNA splicing are spatially and temporally coordinated, and protein phosphorylation regulates both se activity and the subnuclear localization of pre-mRNA splicing factors in nuclear subcompartments.