Nanoporous polymer ring resonators for biosensing.
Nanoporous polymer ring resonators for biosensing.
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DOI：
10.1364/oe.20.000245
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发表时间：
2012-01-02
期刊：
影响因子：
3.8
通讯作者：
Erickson D
中科院分区：
文献类型：
--
作者：
Mancuso M;Goddard JM;Erickson D
光学谐振器件是有前途的无标记的生物分子传感器，由于它们的能力，集中到小模式体积的电磁能量和它们的能力，用于多路检测。当前光学生物传感器技术的基本限制是生物分子相互作用限于谐振装置的表面，而最高强度的电磁能量被捕获在核心内。在本文中，我们提出了纳米多孔聚合物光流体器件组成的环形谐振器耦合到总线波导。我们报告了40%的聚合物装置的灵敏度增加归因于增加核心能量-生物分析物的相互作用。
Optically resonant devices are promising as label-free biomolecular sensors due to their ability to concentrate electromagnetic energy into small mode volumes and their capacity for multiplexed detection. A fundamental limitation of current optical biosensor technology is that the biomolecular interactions are limited to the surface of the resonant device, while the highest intensity of electromagnetic energy is trapped within the core. In this paper, we present nanoporous polymer optofluidic devices consisting of ring resonators coupled to bus waveguides. We report a 40% increase in polymer device sensitivity attributed to the addition of core energy- bioanalyte interactions.