DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF NICERGOLINE IN THE TREATMENT OF PRURITUS IN PATIENTS RECEIVING MAINTENANCE HEMODIALYSIS
DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF NICERGOLINE IN THE TREATMENT OF PRURITUS IN PATIENTS RECEIVING MAINTENANCE HEMODIALYSIS
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DOI：
10.1016/0091-6749(89)90021-3
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发表时间：
1989-04-01
影响因子：
14.2
通讯作者：
MION, C
中科院分区：
文献类型：
--
作者：
BOUSQUET, J;RIVORY, JP;MION, C
瘙痒是长期血液透析患者的常见症状。研究了尼麦角林(一种麦角林)对透析过程中释放的产品中瘙痒的影响。在第一个实验系列中，20名年龄匹配的正常人、25名接受无瘙痒的血液透析患者和15名接受血液透析伴瘙痒的患者进行了500微克罂粟碱的皮内试验。所有瘙痒患者的罂粟碱皮试反应都很小，平均值显著(p<；0.0001)。Mann-Whitney U检验)在有瘙痒症状的患者中较小。所有有瘙痒症的患者都参加了尼麦角林的交叉双盲试验。在六次透析的第一阶段，他们要么服用尼麦角林(每日口服剂量，30毫克，透析期间静脉剂量，5毫克)，要么服用安慰剂。在六次透析的第二阶段，患者接受交叉治疗。尼麦角林对13/15名患者有效，其中8名患者瘙痒症状完全缓解。停用尼麦角林后，患者在24至48小时内复发。所有在试验期间有所改善的患者随后接受为期6个月的每日30毫克尼麦角林治疗。7名患者完全缓解，5名患者有中度症状，1名患者复发。这项研究表明，一些原因不明的瘙痒症血液透析患者使用尼麦角林后有改善。
Pruritus is a common symptom among patients undergoing long-term hemodialysis. The effect of nicergoline, an ergoline, on pruritus was studied in products released during dialysis. In a first experiment series, 20 age-matched normal individuals, 25 patients receiving hemodialysis without pruritus, and 15 patients receiving hemodialysis with pruritus had intradermal tests with 500 .mu.g of papaverine. All patients with pruritus had a small papaverine skin test response, and mean values were significantly (p < 0.0001. Mann-Whitney U test) smaller in patients with pruritus. All patients with pruritus entered in a crossover, double-blind trial with nicergoline. In a first period of six dialyses, they received either nicergoline (daily oral dose, 30 mg, and intravenous dose during dialyses, 5 mg) or placebo. In the second period of six dialyses, patients received the crossover treatment. Nicergoline was effective in 13/15 patients, eight of these patients having a complete remission of prurius. When nicergoline was stopped, patients relapsed within 24 to 48 hours. All patients who improved during the trial were then treated with a daily dose of 30 mg of nicergoline for 6 months. Seven patients had a complete remission, five had moderate symptoms, and one patient relapsed. This study demonstrated that some hemodialyzed patients with pruritus of unknown etiology had improvement with nicergoline.