Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility
Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility
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DOI：
10.1093/humrep/deh664
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发表时间：
2005-03-01
影响因子：
6.1
通讯作者：
Tanbo, T
中科院分区：
文献类型：
--
作者：
Omland, AK;Åbyholm, T;Tanbo, T
背景：本研究是为了比较不明原因和子宫内膜异位症相关不孕症的IVF和ICSI后妊娠结局，以输卵管因素不孕症为对照。方法：这是一项通过血清hCG测量证实的早期IVF/ICSI妊娠的回顾性队列研究，比较了原因不明（n=274）和轻度子宫内膜异位症相关（n=212）与输卵管因素（n=540）不孕症作为对照的后续结果。从1990年1月到2002年12月，1026例IVF或ICSI治疗后的受孕周期符合纳入标准。结果：不明原因不孕不育组（78.8、23.5和11.7%）的活产率、双胎移植率和妊娠6周前流产率均高于子宫内膜异位症相关不孕不育组（66.0、15.0和19.3%）和输卵管因素不孕不育组（66.7、18.1和18.0%）
BACKGROUND: This study was undertaken in order to compare pregnancy outcome after IVF and ICSI in unexplained and endometriosis-associated infertility using tubal factor infertility as controls. METHODS: This was a retrospective cohort study of early IVF/ICSI pregnancies verified by serum hCG measurement, comparing the subsequent outcome in unexplained (n=274) and minimal endometriosis-associated (n=212) with tubal factor (n=540) infertility as controls. From January 1990 to December 2002, 1026 conception cycles after treatment with IVF or ICSI complied with the inclusion criteria. RESULTS: Live birth rate, twin birth rate after transfer of two embryos and abortion rate prior to 6 weeks of gestation were superior for the unexplained (78.8, 23.5 and 11.7%) compared to endometriosis-associated (66.0, 15.0 and 19.3%) and tubal factor (66.7, 18.1 and 18.0%) infertility groups (P