A case-control study of myelodysplastic syndromes in Belgrade (Serbia Montenegro)
A case-control study of myelodysplastic syndromes in Belgrade (Serbia Montenegro)
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DOI：
10.1007/s00277-006-0128-y
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发表时间：
2006-08-01
影响因子：
3.5
通讯作者：
Brkic, Nenad
中科院分区：
文献类型：
--
作者：
Pekmezovic, Tatjana;Vukovic, Nada Suvajdzic;Brkic, Nenad
该研究的目的是调查与贝尔格莱德（塞尔维亚和黑山）人群中骨髓增生异常综合征（MDS）发生相关的因素。2000-2003年期间进行了病例对照研究。研究小组包括80名新诊断的MDS患者和160名性别和年龄匹配的非恶性和非传染性疾病的医院对照。对照组的疾病类别为循环系统疾病（51例，32%）、胃肠道疾病（53例，33%）和眼科疾病（56例，35%）。采用条件单变量和多变量逻辑回归分析。多因素分析显示，以下因素与MDS显著相关：接触化学物质（OR=10.8, 95%CI 3.2-36.2, p=0.0001）、病毒上呼吸道感染（一年两次或以上，OR=5.8, 95%CI 2.5-13.6, p=0.0001）、接触杀虫剂、农药和除草剂（OR=5.2, 95%CI 1.8-15.1, p=0.003）、咖啡（OR=5.1, 95%CI 1.9-13.7, p=0.001）和饮酒（OR=2.2, 95%CI 1.1-4.6, p=0.033）。这些发现支持了这样的假设，即暴露于化学制剂、杀虫剂、杀虫剂和除草剂、某些生活方式因素（饮酒和喝咖啡）以及频繁的病毒感染可能与MDS的病因有关，但这些结果需要进一步的调查来证实。
The objective of the study was to investigate factors related to the occurrence of myelodysplatic syndromes (MDS) in the population of Belgrade (Serbia Montenegro). The case-control study was conducted during the period 2000-2003. The study group consisted of 80 newly diagnosed MDS patients and 160 sex- and age-matched hospital controls with nonmalignant and noninfectious diseases. The disease categories in the control group were circulatory (51 patients, 32%), gastrointestinal (53 patients, 33%), and ophthalmological (56 patients, 35%) disorders. Conditional univariate and multivariate logistic regression analyses were applied. Multivariate analysis showed the following factors to be significantly related to MDS: exposure to chemicals (OR=10.8, 95%CI 3.2-36.2, p=0.0001), viral upper respiratory tract infections (twice a year or more, OR=5.8, 95%CI 2.5-13.6, p=0.0001), exposure to insecticides, pesticides and herbicides (OR=5.2, 95%CI 1.8-15.1, p=0.003), coffee (OR=5.1, 95%CI 1.9-13.7, p=0.001), and alcohol consumption (OR=2.2, 95%CI 1.1-4.6, p=0.033). The findings support the hypotheses that exposure to chemical agents, pesticides, insecticides, and herbicides, certain lifestyle factors (alcohol and coffee consumption), and frequent viral infections may be involved in the etiology of MDS, but these results should be confirmed by further investigations.