Binge drinking in midlife and dementia risk
Binge drinking in midlife and dementia risk
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DOI：
10.1097/01.ede.0000181307.30826.6c
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发表时间：
2005-11-01
期刊：
影响因子：
5.4
通讯作者：
Kaprio, J
中科院分区：
文献类型：
--
作者：
Järvenpää, T;Rinne, JO;Kaprio, J
背景：研究饮酒对认知功能的长期影响的研究产生了相互矛盾的结果。我们的目标是要确定是否长期的随访期结合饮酒模式的信息，除了总的酒精消费量，将提供新的见解酒精使用与痴呆risk.Methods的关系：一个以人口为基础的队列的554芬兰双胞胎，谁提供了数据，在1975年和198年1月的问卷调查中的酒精消费量，随访了25年。受试者在1999-2001年进行痴呆评估时年龄为65岁或以上。痴呆症的风险进行了分析，就不同模式的酒精使用的对数线性modeling，调整年龄，性别，和education.Results：随访结束时，103名参与者已经发展成痴呆症。根据1975年的报告，酗酒（即至少每月一次饮酒超过5瓶啤酒或一瓶葡萄酒）与痴呆症的相对风险为3.2（95%置信区间= 1.2-8.6）相关。在1981年的报告中，在前一年中由于过度饮酒而至少两次昏倒与饮酒者痴呆的相对风险为10.5（2.4-46）相关。结论：中年酗酒与痴呆风险增加相关。
Background: Studies examining the long-term effects of alcohol consumption on cognitive functioning have produced conflicting results. Our goal was to determine whether a long follow-up period combined with information about drinking patterns, in addition to total alcohol consumption, would provide new insights about the relationship of alcohol use with dementia risk.Methods: A population-based cohort of 554 Finnish twins, who had provided data on alcohol consumption in questionnaires in 1975 and 198 1, was followed for 25 years. Subjects were age 65 years or older at the time of dementia assessment in 1999-2001. Dementia risk was analyzed with respect to varying patterns of alcohol use by log-linear modeling, adjusted for age, sex, and education.Results: By the end of follow-up, 103 participants had developed dementia. Binge drinking (ie, alcohol exceeding the amount of 5 bottles of beer or a bottle of wine on I occasion at least monthly), as reported in 1975, was associated with a relative risk of 3.2 (95% confidence interval = 1.2-8.6) for dementia. Passing out at least twice as a result of excessive alcohol use during the previous year, as reported in 1981, was associated with a relative risk of 10.5 (2.4-46) for dementia in drinkers.Conclusions: Binge drinking in midlife is associated with an increased risk of dementia.