Abnormal age-related changes of plasma antioxidant proteins in schizophrenia
Abnormal age-related changes of plasma antioxidant proteins in schizophrenia
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DOI：
10.1016/s0165-1781(00)00230-4
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发表时间：
2000-12
影响因子：
11.3
通讯作者：
J. Yao;R. Reddy;D. Kammen
中科院分区：
文献类型：
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作者：
J. Yao;R. Reddy;D. Kammen
白蛋白和胆红素是金属结合蛋白，具有清除自由基的特性，因此可能是选择性抗氧化剂。在本研究中，我们检查了精神分裂症患者的个体血浆抗氧化剂（例如白蛋白和胆红素）是否减少，这些抗氧化剂对总抗氧化状态（TAS）有显着贡献。我们前瞻性研究了血浆抗氧化蛋白，即白蛋白和胆红素，在男性退伍军人精神分裂症患者中使用受试者内，重复测量，开-关-开氟哌啶醇治疗设计，以及年龄和性别匹配的健康志愿者。与年龄和性别匹配的健康志愿者（n= 31）相比，氟哌啶醇治疗期间（n=46）或无药物条件下（n= 35）的男性精神分裂症患者的血浆白蛋白和胆红素水平均显著降低。与健康志愿者相比，精神分裂症患者血浆抗氧化蛋白的减少似乎是与年龄相关的变化。另一方面，血浆白蛋白和胆红素水平不受氟哌啶醇治疗、氟哌啶醇停药或停药期长短的显著影响。此外，血浆TAS不受吸烟的显著影响，即使它可能选择性地降低血浆胆红素，但不降低白蛋白水平。目前的研究结果，结合我们以前的结果，减少血浆TAS和尿酸，以及增加红细胞超氧化物歧化酶，提供进一步支持的假设，即在抗氧化防御系统的缺陷存在于精神分裂症，可能会导致氧化损伤。
Albumin and bilirubin are metal-binding proteins, shown to possess free radical scavenging properties, and may thus be selective antioxidants. In the present study we examined whether individual plasma antioxidants such as albumin and bilirubin, which significantly contribute to total antioxidant status (TAS), are reduced in patients with schizophrenia. We prospectively studied plasma antioxidant proteins, i.e. albumin and bilirubin, in male veteran schizophrenic patients using a within-subject, repeated measures, on–off–on haloperidol treatment design, as well as age- and sex-matched healthy volunteers. Male patients with schizophrenia either during haloperidol treatment (n=46) or in a drug-free condition (n=35) had significantly lower levels of both plasma albumin and bilirubin compared with age- and sex-matched healthy volunteers (n=31). Such reductions of plasma antioxidant proteins in schizophrenic patients appear to be age-related changes, in contrast to those observed in healthy volunteers. On the other hand, levels of plasma albumin and bilirubin were not significantly affected by haloperidol treatment, haloperidol withdrawal, or length of drug-free period. Moreover, plasma TAS was not influenced significantly by cigarette smoking, even though it may selectively decrease plasma bilirubin but not albumin levels. The present findings, taken together with our previous results of reduced plasma TAS and uric acid, as well as an increased Red blood cell superoxide dismutase, lend further support to the hypothesis that a defect in the antioxidant defense system exists in schizophrenia that may lead to oxidative damage.