A hamster model of equine herpesvirus type 1 (EHV-1) infection; passive protection by monoclonal antibodies to EHV-1 glycoproteins 13, 14 and 17/18.
A hamster model of equine herpesvirus type 1 (EHV-1) infection; passive protection by monoclonal antibodies to EHV-1 glycoproteins 13, 14 and 17/18.
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1型马疱疹病毒（EHV-1）感染的仓鼠模型；
DOI：
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发表时间：
1989
影响因子：
3.8
通讯作者：
P. K. Murray
中科院分区：
文献类型：
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作者：
A. Stokes;G. Allen;L. Pullen;P. K. Murray
Following intraperitoneal or intranasal inoculation of the Syrian hamster with equine herpesvirus type 1 (EHV-1), strain Kentucky D, virus replicated in the liver and lungs reaching a peak at 4 days post-infection (p.i.). By day 6 p.i. virus titres in these organs had reduced and the spleen contained virus-specific cytotoxic cells. This cytotoxicity was mediated by T cells since treatment of effector cells with a monoclonal antibody to hamster T lymphocytes inhibited the effect. An antiviral humoral immune response was present by day 4 when antibodies capable of lysing EHV-1-infected target cells in the presence of complement were detected. The transfer of serum from recovered hamsters into naive recipients 24 h before challenge prevented virus infection, whereas serum transferred 24 h after challenge reduced the titre of virus recovered from target organs. Inoculation of hamsters with monoclonal antibodies directed to glycoproteins 13, 14 and 17/18 of a subtype 1 virus (Army 183) before virus challenge protected hamsters. This hamster model will prove useful for studying the immune response to EHV-1 and evaluating the immunogenicity of individual virus components.
流感感染肺部的局部细胞防御。
影响因子：
4.3
作者：
Stein-Streilein,J;Witte,PL;Streilein,JW;Guffee,J
通讯作者：
Guffee,J
描述叙利亚仓鼠中介导辅助/DTH 和细胞毒功能的表型不同的 T 淋巴细胞亚群。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Witte,PL;Stein-Streilein,J;Streilein,JW
通讯作者：
Streilein,JW
叙利亚仓鼠 I 类基因的结构。
DOI：
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发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
McGuire,KL;Duncan,WR;Tucker,PW
通讯作者：
Tucker,PW