Regulation of body fat in Caenorhabditis elegans.
Regulation of body fat in Caenorhabditis elegans.
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DOI：
10.1146/annurev-physiol-021014-071704
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发表时间：
2015
影响因子：
18.2
通讯作者：
Srinivasan S
中科院分区：
文献类型：
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作者：
Srinivasan S
在C.在过去的十年里，elegans强调了身体脂肪调节的古老而复杂的起源。在这篇评论中，我介绍了用于研究能量平衡和体脂的主要功能方法，C。细胞脂肪代谢的调控及其转录调控。接下来，我描述了感觉神经系统对身体脂肪的影响，以及将神经系统中的食物感知与通过脂肪代谢产生能量相结合的主要调节机制。最后一节描述了发现神经内分泌因子的机会，这些因子控制神经系统和代谢组织之间的交流。在未来的几年里，我们有望发现大量关于C.优美的
Studies conducted in C. elegans over the last decade highlight the ancient and complex origins of body fat regulation. In this critical review, I introduce the major functional approaches used to study energy balance and body fat, the lipid composition of C. elegans, the regulation of cellular fat metabolism and its transcriptional control. Next I describe the influence of the sensory nervous system on body fat and the major regulatory mechanisms that couple food perception in the nervous system with the production of energy via fat metabolism. The final section describes the opportunities for the discovery of neuroendocrine factors that control communication between the nervous system and the metabolic tissues. The coming years are expected to reveal a wealth of information on the neuroendocrine control of body fat in C. elegans.