An Experimental Model of Alcohol Feeding and Liver Injury in the Baboon 1
An Experimental Model of Alcohol Feeding and Liver Injury in the Baboon 1
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狒狒酒精喂养和肝损伤的实验模型 1
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
L. Decarli
中科院分区：
文献类型：
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作者：
Charles S. Lieber;L. Decarli
已经开发出一种模型，可以将乙醇作为营养充足的流质饮食的一部分给狒狒服用。通过这种方案，所有动物都保持了体重，对照组的肝脏形态也正常。用乙醇等热量替代碳水化合物（占总热量的50%）会导致所有动物产生脂肪肝，同时一些动物还出现酒精性肝炎和肝硬化，血清谷草酰乙酸转氨酶活性增加。观察到醉酒和对戒断饮食的依赖表现。脂肪肝阶段乙醇产生的化学变化的特点是甘油三酯显着积累和微粒体酶活性增强，包括微粒体乙醇氧化系统（MEOS）。
A model has been developed for the administration to the baboon of ethanol as part of a nutritionally adequate liquid diet. With this regimen, all animals maintained their weight, and liver morphology was normal in the controls. Isocaloric substitution of carbohydrate (50% of total calories) by ethanol resulted in the production of fatty liver in all animals, while some also developed alcoholic hepatitis and cirrhosis with increased activities of serum glutamic oxaloacetic transaminase. Inebriation and manifestation of dependence upon withdrawal of the diet were observed. Chemical alterations produced by ethanol at the fatty liver stage were characterized by striking triglyceride accumulation and enhanced activities of microsomal enzymes, including the microsomal ethanol oxidizing system (MEOS).