A METAANALYSIS OF BODY-MASS INDEX AND RISK OF PREMENOPAUSAL BREAST-CANCER
A METAANALYSIS OF BODY-MASS INDEX AND RISK OF PREMENOPAUSAL BREAST-CANCER
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DOI：
10.1097/00001648-199503000-00009
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发表时间：
1995-03-01
期刊：
影响因子：
5.4
通讯作者：
GREENLAND, S
中科院分区：
文献类型：
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作者：
URSIN, G;LONGNECKER, MP;GREENLAND, S
体重指数（BMI）的增加与绝经后乳腺癌的风险增加有关。BMI是否与绝经前乳腺癌有关尚未确定。我们对23项研究的数据进行了荟萃分析，这些研究提供了BMI和绝经前乳腺癌发病率的信息。总体而言，数据支持适度的逆关联。对于BMI差异为8 kg/m2的人群，即瘦人与病态肥胖者之间的差异，四项队列研究的随机效应估计率比为0.70 [95%置信区间（CI）= 0.54-0.91]，19个病例对照研究的随机效应OR值为0.88（95%CI = 0.76-1.02）。然而，由于研究特定估计值之间存在实质性异质性，我们还检查了研究设计某些方面的影响。与社区对照的病例对照研究有更多的负相关，而病例对照研究，在诊断后不久的情况下，对病例和对照采用相同的排除标准，或调整年龄以外的混杂因素，BMI和乳腺癌之间有更积极的相关性。病例对照研究之间的差异的可能原因进行了讨论。
Increased body mass index (BMI) has been found to be associated with elevated risk of postmenopausal breast cancer. Whether BMI is related to premenopausal breast cancer has not yet been established. We performed a meta-analyses of data from 23 studies that provided information on BMI and incidence of premenopausal breast cancer. Overall, the data support a modest inverse association. For a BMI difference of 8 kg per m(2), that is, the difference between a thin person and someone who is morbidly obese, the random effects estimate of the rate ratio from the four cohort studies was 0.70 [95% confidence interval (CI) = 0.54-0.91], and the random effects estimate of the odds ratio from the 19 case control studies was 0.88 (95% CI = 0.76-1.02). Because of substantial heterogeneity among the study-specific estimates, however, we also examined the influence of certain aspects of study design. Case-control studies with community controls had a more inverse association, whereas case-control studies that inter viewed cases shortly after diagnosis applied the same exclusion criteria to cases and controls, or with confounder adjustment beyond age had a more positive association between BMI and breast cancer. Possible reasons for the discrepancies among the case-control studies are discussed.