Effects of metabolite correction for arterial input function on quantitative receptor images with 11C-flumazenil in clinical positron emission tomography studies
Effects of metabolite correction for arterial input function on quantitative receptor images with 11C-flumazenil in clinical positron emission tomography studies
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DOI：
10.1097/00004728-200405000-00021
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发表时间：
2004-05-01
影响因子：
1.3
通讯作者：
Yonekura, Y
中科院分区：
文献类型：
--
作者：
Okazawa, H;Yamauchi, H;Yonekura, Y
目的：评估不同代谢物校正方法估计的输入对 (11)C-氟马西尼 (FMZ) 结合电位 (BP) 的影响。方法：五名健康志愿者接受 (11)C-FMZ 正电子发射断层扫描。采集动脉血样本以获得血浆放射性和代谢物分数，然后用多种方法估计输入函数。计算了不同输入功能的结合潜力图像和使用非侵入性图形方法的结合潜力图像。还比较了不同采集时间的标准化摄取值（SUV）图像。结果：无论代谢物校正方法以及无创绘图方法如何，从动脉输入计算的结合电位图像几乎相同，并且区域值没有显着差异。与定量 BP 图像相比，标准化摄取值图像显示出较低的对比度，并且区域值根据扫描时间而变化。统计参数映射分析显示BP和SUV图像之间存在显着的区域差异。结论：无论计算方法如何，结合潜力图像都是等效的；但SUV不适合定量评价。
Objective: To evaluate the effect of inputs estimated from different methods for metabolite correction on binding potential (BP) of (11)C-flumazenil (FMZ).Methods: Five healthy volunteers underwent (11)C-FMZ positron emission tomography. Arterial blood was sampled to obtain plasma radioactivity and metabolite fraction, followed by estimation of input functions with several methods. Binding potential images for different input functions and that using the noninvasive graphic method were calculated. Images of standardized uptake value (SUV) with different acquisition times were also compared.Results: Binding potential images calculated from arterial inputs were almost equivalent, and regional values were not significantly different irrespective of methods for metabolite correction as well as the noninvasive graphic plot method. Standardized uptake value images showed less contrast compared with quantitative BP images, and the regional values varied depending on scan time. Statistical parametric mapping analysis showed significant regional differences between BP and SUV images.Conclusion: Binding potential images were equivalent irrespective of calculation methods; however, SUV was not appropriate for quantitative evaluation.