Mode of infection of Hokkaido virus (Genus hantavirus) among grey red-backed voles, Myodes rufocanus, in Hokkaido, Japan
Mode of infection of Hokkaido virus (Genus hantavirus) among grey red-backed voles, Myodes rufocanus, in Hokkaido, Japan
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DOI：
10.1111/j.1348-0421.2007.tb04003.x
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Takashima, Ikuo
中科院分区：
文献类型：
--
作者：
Abu Daud, Nur Hardy;Kariwa, Hiroaki;Takashima, Ikuo
北海道病毒(HOKV)属于汉坦病毒属，隶属于布尼亚病毒科。为了调查灰红背田鼠宿主红背田鼠的HOKV感染情况，在日本北海道的Toetsu(2004年10月和2005年7月)和Nakagawa(2004年10月)捕获了199只动物，检测抗体、抗原和病毒RNA。在托贝苏(2004年)和中川(2004年)的调查中，血清阳性动物的发生率分别为6.0%(5/84)和10.4%(5/48)。2005年，托贝苏没有发现有血清阳性的动物。2004年托贝津和中川地区男性血清阳性率分别为25%(1/4)和45.5%(5111)，高于女性的5.0%(4/80)和0%(0/37)(P=10倍于持续感染动物的肺部RNA拷贝数)。在大多数情况下，无论感染状态如何，肺或脾的RNA拷贝数都最高。
Hokkaido virus (HOKV) is a member of the genus Hantavirus, in the family Bunyaviridae. To investigate HOKV infection in the host Myodes rufocanus, the grey red-backed vole, 199 animals were captured at Tobetsu (October 2004 and July 2005) and Nakagawa (October 2004) in Hokkaido, Japan, for detection of antibody, antigen, and viral RNA. In the surveys in Tobetsu (2004) and Nakagawa (2004), seropositive animals were detected at a frequency of 6.0% (5/84) and 10.4% (5/48), respectively. No seropositive animals were detected in Tobetsu in 2005. Seroprevalence in males in Tobetsu and Nakagawa in 2004 was 25 % (1/4) and 45.5 % (5111), respectively, which was higher than in females, at 5.0 % (4/80) and 0% (0/37), respectively (P= 10 times the number of RNA copies in their lungs compared to those of persistently infected animals. In most cases, lungs or spleen had the highest RNA copy number, regardless of infection status.