Extreme Concentrations of Endogenous Sex Hormones, Ischemic Heart Disease, and Death in Women
Extreme Concentrations of Endogenous Sex Hormones, Ischemic Heart Disease, and Death in Women
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DOI：
10.1161/atvbaha.114.304821
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发表时间：
2015-02-01
影响因子：
8.7
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
--
作者：
Benn, Marianne;Voss, Sidsel Skou;Nordestgaard, Borge G.
目的：性激素可能是女性缺血性心脏病和死亡的关键决定因素，但以往的研究结果相互矛盾。为了澄清这一点，我们检验了内源性雌二醇和睾酮的血浆浓度过高与女性缺血性心脏病和死亡风险相关的假设。方法和结果：在一项嵌套的前瞻性队列研究中，我们测量了1981年至1983年哥本哈根城市心脏研究中4600名未接受口服避孕药或激素替代治疗的妇女的血浆雌二醇和4716名未接受口服避孕药或激素替代治疗的妇女的总睾酮。在
Objective-Sex hormones may be critical determinants of ischemic heart disease and death in women, but results from previous studies are conflicting. To clarify this, we tested the hypothesis that extreme plasma concentrations of endogenous estradiol and testosterone are associated with risk of ischemic heart disease and death in women.Approach and Results-In a nested prospective cohort study, we measured plasma estradiol in 4600 and total testosterone in 4716 women not receiving oral contraceptives or hormonal replacement therapy from the 1981 to 1983 examination of the Copenhagen City Heart Study. During