Progesterone receptor immunoreactivity in the brains of ovariectomized aged rats.
Progesterone receptor immunoreactivity in the brains of ovariectomized aged rats.
复制标题
卵巢切除老年大鼠大脑中黄体酮受体的免疫反应性。
DOI：
10.1097/wnr.0b013e32833c5b6f
复制
发表时间：
2010
期刊：
影响因子：
1.7
通讯作者：
Funabashi T.
中科院分区：
文献类型：
--
作者：
Furuta M;Fukushima A;Chiba S;Sano A;Akema T;Kimura F;Funabashi T.
We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir cells in the preoptic area and ventromedial hypothalamic nucleus in young rats. Cholesterol-treated old rats had very few PR-ir cells; estrogen treatment significantly increased the number of PR-ir cells in both the preoptic area and the ventromedial hypothalamic nucleus in old rats, although less than in young rats. Therefore, the ability of estrogen to induce PR immunoreactivity in the hypothalamus in ovariectomized rats is attenuated in old rats compared with young rats.
