COMPARISON OF FIXED-RATIO AND PROGRESSIVE-RATIO SCHEDULES OF MAINTENANCE OF STIMULANT DRUG-REINFORCED RESPONDING
COMPARISON OF FIXED-RATIO AND PROGRESSIVE-RATIO SCHEDULES OF MAINTENANCE OF STIMULANT DRUG-REINFORCED RESPONDING
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DOI：
10.1016/0376-8716(85)90036-5
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发表时间：
1985-01-01
影响因子：
4.2
通讯作者：
WOODS, JH
中科院分区：
文献类型：
--
作者：
WINGER, G;WOODS, JH
在固定比和渐进比（FR， PR）两种方案下，对静脉注射可卡因和诺非芬维持恒河猴杠杆按压反应的有效性进行了评估。在固定比例方案下保持最大反应率的剂量为每次注射可卡因0.32 mg/kg和每次注射诺非芬0.10 mg/kg。这种剂量的诺非芬维持的固定比率略低于可卡因维持的固定比率。在递进比率方案下，每次注射可卡因0.32 mg/kg和诺非芬0.32 mg/kg时，反应率最高。在递进比下，可卡因的最大表现略高于诺非芬。递进比例表可能产生药物相对强化效应的信息，与固定比例表所获得的信息仅略有不同。
The effectiveness of doses of i.v. cocaine and nomifensine in maintaining lever-press responding in rhesus monkeys was evaluated under 2 schedules, fixed- and progressive-ratio (FR, PR). The doses that maintained maximum rates of responding under the fixed-ratio schedule were 0.32 mg/kg per injection cocaine and 0.10 mg/kg per injection nomifensine. The fixed-ratio rates maintained by this dose of nomifensine were slightly lower than those maintained by cocaine. Under the progressive-ratio schedule, the maximum response rates developed with 0.32 mg/kg per injection cocaine and 0.32 mg/kg per injection nomifensine. Maximum performances under the progressive ratio were slightly higher with cocaine than with nomifensine. Progressive-ratio schedules may yield information on the relative reinforcing effects of drugs that differs only slightly from that obtained with fixed-ratio schedules.