The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases.
The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases.
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快速分散崩解的壳聚糖片剂的制备和验证，作为口腔吸附剂治疗生活方式相关疾病。
DOI：
10.1016/j.carbpol.2020.117246
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发表时间：
2021
影响因子：
11.2
通讯作者：
Hirayama F.
中科院分区：
文献类型：
--
作者：
Anraku M;Mizukai Y;Maezaki Y;Kawano K;Okazaki S;Takeshita K;Adachi T;Otagiri M;Iohara D;Hirayama F.
以壳聚糖（G-CS）颗粒为原料，制备了一种用于治疗慢性病的载体和片剂形式的口腔吸收剂。所得片剂在水性介质中高度分散并快速崩解（< 30 s）。在湿法制粒过程中，未制粒的壳聚糖（N-CS）粉末部分结晶（2θ = 12 - 15°和20°），得到G-CS结晶颗粒。水渗透到G-CS聚集体中的速率明显快于N-CS聚集体，如片剂易于崩解所证明。大鼠经口给予两种片剂后，通过MRI测量证实了片剂在体内的快速崩解和分散。某些尿酸毒素吸附更强烈，以G-CS片比N-CS片。结果表明，G-CS片具有很大的潜力，作为一个快速崩解的载体，并作为一个口腔吸附剂在生活方式相关的疾病。
A carrier and an oral absorbent for the treatment of chronic diseases in the form of a tablet was prepared from granulated chitosan (G-CS) particles. The resulting tablet was highly dispersible and disintegrated rapidly (< 30 s) in aqueous media. The non-granulated chitosan (N-CS) powder partially crystallized (2θ = 12−15° and 20°) during wet granulation to give G-CS crystalline particles. The rate of penetration of water into G-CS aggregates was markedly faster than that for N-CS aggregates, as evidenced by the ease of disintegration of the tablets. The rapid disintegration and dispersion of the tabletsin vivowas confirmed by MRI measurements after the oral administration of the both tablets to rats. Some ureic toxins were adsorbed more strongly to G-CS tablets than on N-CS tablets. The results suggest that G-CS tablets have great potential for use as a fast disintegrating carrier and as an oral adsorbent in lifestyle-related diseases.
《临床药物数据手册》。
影响因子：
14.6
作者：
J. Knoben;P. Anderson
通讯作者：
P. Anderson