Regulation of thermoregulatory behavior by commensal bacteria in <i>Drosophila</i>
Regulation of thermoregulatory behavior by commensal bacteria in <i>Drosophila</i>
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果蝇共生细菌对体温调节行为的调节
DOI：
10.1093/bbb/zbac087
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Umeda Masato
中科院分区：
文献类型：
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作者：
Suito Takuto;Nagao Kohjiro;Juni Naoto;Hara Yuji;Sokabe Takaaki;Atomi Haruyuki;Umeda Masato
共生细菌影响宿主生理的许多方面。本研究以果蝇为研究对象，探讨了肠道细菌在果蝇体温调节行为中的作用。我们证明，消除肠道细菌引起果蝇幼虫偏好温度的增加，而不影响瞬时受体电位锚蛋白1（TRPA 1）表达的热敏神经元的活性。我们从常规饲养的幼虫的肠道和培养基中分离出8株细菌，发现与植物乳杆菌或努鲁基棒状杆菌的单结合降低了幼虫的偏好温度。与这些细菌的单一关联并不影响能量代谢指标，如ATP和葡萄糖水平的幼虫，这是密切相关的动物体温调节。因此，我们显示了一个新的作用，寄生细菌在宿主的体温调节，并确定两种细菌物种，影响果蝇的体温调节行为。
Commensal bacteria affect many aspects of host physiology. In this study, we focused on the role of commensal bacteria in the thermoregulatory behavior ofDrosophila melanogaster. We demonstrated that the elimination of commensal bacteria caused an increase in the preferred temperature ofDrosophilathird-instar larvae without affecting the activity of transient receptor potential ankyrin 1 (TRPA1)-expressing thermosensitive neurons. We isolated eight bacterial strains from the gut and culture medium of conventionally reared larvae and found that the preferred temperature of the larvae was decreased by mono-association withLactobacillus plantarumorCorynebacterium nuruki. Mono-association with these bacteria did not affect the indices of energy metabolism such as ATP and glucose levels of larvae, which are closely linked to thermoregulation in animals. Thus, we show a novel role for commensal bacteria in host thermoregulation and identify two bacterial species that affect thermoregulatory behavior inDrosophila.