Abnormal corticomotor excitability assessed in biceps brachii preceding pronator contraction post-stroke
Abnormal corticomotor excitability assessed in biceps brachii preceding pronator contraction post-stroke
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DOI：
10.1016/j.clinph.2007.11.004
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发表时间：
2008-03-01
影响因子：
4.7
通讯作者：
Stinear, James W.
中科院分区：
文献类型：
--
作者：
Gerachshenko, Tatyana;Rymer, W. Zev;Stinear, James W.
目的：探讨脑卒中后拮抗肌肱二头肌（BB）的皮质运动（CM）兴奋性，为旋前肌收缩做准备。在健康受试者中，我们以前证明，旋前肌收缩CM兴奋性的拮抗剂BB被suppressed.Methods：经颅磁刺激（TMS）被用来评估收缩前的变化，运动诱发电位（MEP）的BB幅度，当BB作为拮抗剂或激动剂。TMS应用于100-200英寸之前，有节奏的等距BB或旋前肌收缩在慢性中风幸存者和年龄/性别匹配的健康controlsubjects.Results：旋前肌收缩，在BB中的MEN引起的中风组，但在健康对照组缺席，表明CM兴奋性的拮抗剂BB增加中风后。兴奋性的异常增加的程度呈正相关的上肢motor impairment.Conclusions的程度：我们的研究结果表明，改变皮质控制机制调节运动兴奋性的拮抗剂BB可能有助于损害上肢运动协调post-stroke.Significance：这项研究提供了一个独特的方法来研究潜在的脑卒中后运动不协调的皮质起源。(C)2007年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To assess corticomotor (CM) excitability of the antagonist biceps brachii (BB) post-stroke in preparation for pronator contraction. In healthy subjects, we previously demonstrated that prior to pronator contraction CM excitability of the antagonist BB was suppressed.Methods: Transcranial magnetic stimulation (TMS) was used to assess pre-contraction changes in motor evoked potential (MEP) amplitude of the BB, when BB was acting either as an antagonist or an agonist. TMS was applied 100-200 ins prior to rhythmic isometric BB or pronator contractions in chronic stroke survivors and age/gender matched healthy control subjects.Results: Prior to pronator contraction, MEN in BB were elicited in the stroke group but were absent in healthy controls indicating that CM excitability of the antagonist BB was increased post-stroke. The extent of the abnormal increase in excitability positively correlated with the extent of upper limb motor impairment.Conclusions: Our results suggest that an alteration of cortical control mechanisms regulating motor excitability of the antagonist BB may contribute to the impairment of upper limb motor coordination post-stroke.Significance: This Study offers a unique approach to Study the potential for a cortical origin of post-stroke motor discoordination. (C) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.