Plasmodium falciparum:: Genetic diversity of C-terminal region of MSP-1 in isolates from Indian sub-continent
Plasmodium falciparum:: Genetic diversity of C-terminal region of MSP-1 in isolates from Indian sub-continent
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DOI：
10.1016/j.exppara.2005.03.027
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发表时间：
2005-08-01
影响因子：
2.1
通讯作者：
Das, A
中科院分区：
文献类型：
--
作者：
Kumar, SV;Ranjan, S;Das, A
疟疾寄生虫对许多阶段特异性抗原表现出序列多样性。许多研究证明裂殖子表面蛋白-1（MSP-1）是一种有效的诱导保护性免疫应答的靶蛋白。MSP-1（42）区包含两个EGF样结构域，参与在人和其它实验动物中产生保护性免疫应答。寻找该区域的点突变对于疫苗开发至关重要。我们调查了印度不同地区的恶性疟原虫MSP-1羧基末端区域的序列变异。我们的研究揭示了MSP-119在印度次大陆的八种变体类型的存在，其包括E-TSR-L、Q-TSR-L、E-TSG-L、Q-KNG-L、Q-KNG-F、E-KNG-L、E-KNG-F和E-KYG-F。最后命名的等位基因是首次报道的新变体。(c)2005年爱思唯尔公司All rights reserved.
Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that merozoite surface protein-1 (MSP-1) is an effective tat-get eliciting a protective immune response. The MSP-1(42) region comprising two EGF-like domains is involved in generating protective immune response in humans and other experimental animals. Searching for point mutations in this region is essential in view of vaccine development. We have investigated the sequence variations in Plasmodium falciparum MSP-1 carboxy terminal region in field isolates from different regions in India. Our study reveals the presence of eight variant types of MSP-1 19 in the Indian sub-continent, which comprise of E-TSR-L, Q-TSR-L, E-TSG-L, Q-KNG-L, Q-KNG-F, E-KNG-L, E-KNG-F, and E-KYG-F. The last named allele is a novel variant being reported for the first time. (c) 2005 Elsevier Inc. All rights reserved.