Manipulation of opiate activity in the amygdala alters memory processes.
Manipulation of opiate activity in the amygdala alters memory processes.
复制标题
操纵杏仁核中的阿片类药物活性会改变记忆过程。
DOI：
10.1016/0024-3205(78)90565-9
复制
发表时间：
1978
期刊：
影响因子：
6.1
通讯作者：
B. Kapp
中科院分区：
文献类型：
--
作者：
M. Gallagher;B. Kapp
阿片受体激动剂，左啡烷，注射到大鼠杏仁核复合体后，被动回避条件产生的时间依赖性和剂量依赖性减少保留。观察到用左啡烷获得的这种效果是立体特异性的。此外，训练后给予阿片拮抗剂纳洛酮，进入杏仁核显着增加保留的被动回避条件反射的时间依赖性和剂量依赖性的方式。最后，阿片激动剂和拮抗剂给药的这些相反作用被左啡烷和纳洛酮联合给药阻断。这些数据支持杏仁核阿片肽在时间依赖性记忆过程中的可能作用。
The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.