Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpme
Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpme
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DOI：
10.1016/j.neulet.2007.04.056
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发表时间：
2007-06-08
影响因子：
2.5
通讯作者：
Freitas, R. M.
中科院分区：
文献类型：
--
作者：
Xavier, S. M.;Barbosa, C. O.;Freitas, R. M.
维生素C（VIT C）是一种外源性抗氧化剂，能够改变脑氧化应激。抗氧化剂在匹鲁卡品诱导的成年大鼠癫痫发作和癫痫持续状态（SE）中表现出一定的抗氧化作用。本研究旨在研究VIT C对首次癫痫发作潜伏期、癫痫发作百分比、死亡率以及癫痫发作和SE后海马脂质过氧化水平和过氧化氢酶活性的影响。用250 mg/kg，i.p.，在毛果芸香碱给药前30分钟（400 mg/kg，s.c.，毛果芸香碱组（P400）。VIT C可延长首次癫痫发作潜伏期，降低死亡率和脂质过氧化水平。在P400 + VIT C和VIT C组中观察到海马过氧化氢酶活性增加。结果提示，维生素C对成年大鼠具有抗氧化和抗惊厥作用，提示维生素C可能通过降低脂质过氧化产物含量和提高过氧化氢酶活性参与SE时自由基形成的脑代偿机制。(c)2007年由Elsevier爱尔兰有限公司出版。
Vitamin C (VIT C) is an exogenous antioxidant able to alter the brain oxidative stress. Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats. This present study was aimed at was investigating the VIT C effects on latency to first seizure, in percentage of seizures, mortality rate, as well as hippocampal lipid peroxidation levels and catalase activity after seizures and SE. The VIT C effects were investigated after the pretreatment with dose 250 mg/kg, i.p., 30 min before pilocarpine administration (400 mg/kg, s.c., pilocarpine group (P400)). The VIT C increase the latency to first seizure and decrease the mortality rate and lipid peroxidation levels. In P400 + VIT C and VIT C groups were observed an increase in hippocampal catalase activity. Our results suggests that the vitamin C can exert antioxidant and anticonvulsive effects in adult rats, suggesting that this vitamin can be able by reduction of lipid peroxidation content and increased of catalase enzymatic activity which cerebral compensatory mechanisms in free radical formation during SE. (c) 2007 Published by Elsevier Ireland Ltd.