Cytotoxic activity of some natural and synthetic guaianolides
Cytotoxic activity of some natural and synthetic guaianolides
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DOI：
10.1021/np0500575
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Lee, KH
中科院分区：
文献类型：
--
作者：
Bruno, M;Rosselli, S;Lee, KH
对几种天然愈创木内酯和合成的repin衍生物（1）进行了测试，发现它们对肿瘤细胞复制有活性。Repin（1）以及单卤代醇和二卤代醇类似物（2、7-9、11、12）均显示出显着的抗肿瘤功效。通过用紫杉醇侧链取代repin得到更有效的化合物（17）。
Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.