Vitamin C concentrations in plasma as a function of intake: A meta-analysis
Vitamin C concentrations in plasma as a function of intake: A meta-analysis
复制标题
DOI：
10.1024/0300-9831.70.5.226
复制
发表时间：
2000-09-01
影响因子：
2.3
通讯作者：
Jordan, P
中科院分区：
文献类型：
--
作者：
Brubacher, D;Moser, U;Jordan, P
本研究的目的是通过荟萃分析估计维生素C的摄入量-血浆关系。MEDLINE检索显示30篇出版物符合我们的纳入标准。我们完成了一套与5个较旧的文件和一个专着。拟议的统计模型纠正了各种研究之间方法差异方面的不一致。因此，特定研究对估计的贡献与数据点的数量无关。对完整的数据集以及不同的亚组进行了估计：15-65岁的“成人”、60-96岁的“老年人”、“非吸烟者”和“吸烟者”。每日维生素C摄入量为60 mg时，血浆浓度的第50百分位数为42.4 μ mol/L。不同亚组的相应值为：“成人”44.1 μ mol/L，“老年人”31.0 μ mol/L，“非吸烟者”42.4 μ mol/L，“吸烟者”33.6 μ mol/L。因此，这项荟萃分析证实了早期的结果，即与“成人”和“非吸烟者”相比，“老年人”和“吸烟者”对维生素C的需求更高，它可用于估计维生素C摄入量，以在目标人群中达到所需的血浆水平。在一般人群中，假设最佳血浆浓度为50 μ mol/L，由共识会议提出，可以通过每天摄入100 mg来实现，这是奥地利，德国和瑞士营养学会的新建议。
The purpose of this study was to estimate the intake - plasma relationship for vitamin C by means of a meta-analysis. A MEDLINE search revealed 30 publications matching our inclusion criteria. We completed the set with 5 older papers and with one monograph. The proposed statistical model corrects for inconsistencies with regard to methodological differences between the various studies. Therefore, the contribution of a particular study to the estimation is independent of the number of data points. The estimations were performed for the complete data set as well as for different subgroups: "adult" aged 15-65 years, "elderly" aged 60-96 years, "non-smoker" and "smokers". The 50th percentile of the plasma concentration for a daily vitamin C intake of 60 mg was 42.4 mu mol/L. The corresponding values for the different subgroups were: "adult" 44,1 mu mol/L, " elderly" 31.0 mu mol/L, "nonsmokers" 42,4 mu mol/L, and "smokers" 33.6 mu mol/L. Thus, this meta-analysis confirms earlier results that the requirements of vitamin C is higher in "elderly" and "smokers" compared to "adult" and "nonsmokers" and it can be used for the estimation of the vitamin C intake in order to achieve a desired plasma level within a target population. In the general population the assumed optimal plasma concentration of 50 mu mol/L, as proposed by a consensus conference, can be achieved by the intake of 100 mg per day, which is the new recommendation of the Austrian, German, and Swiss Nutrition Societies.