Target platelet antigen in homosexual men with immune thrombocytopenia.
Target platelet antigen in homosexual men with immune thrombocytopenia.
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患有免疫性血小板减少症的同性恋男性的目标血小板抗原。
DOI：
10.1056/nejm198511283132202
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Shuman,MA
中科院分区：
文献类型：
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作者：
Stricker,RB;Abrams,DI;Corash,L;Shuman,MA
孤立性免疫性血小板减少性紫癜（ITP）综合征最近在同性恋男性中被描述。我们在30名患有分离性ITP的男同性恋者中29人的血清中发现了一种抗血小板抗体。该抗体与25000道尔顿的血小板膜抗原结合，并受免疫球蛋白F(ab)2部分的影响。在30例非同性恋ITP或非免疫性血小板减少症患者的血清中未检测到类似的抗体活性。25000道尔顿抗原未在其他造血细胞中发现，它与艾滋病相关逆转录病毒的核心蛋白不同。相反，血清抗体与培养的单纯疱疹病毒I型和II型相关的25000道尔顿抗原反应。在这些实验中，抗原似乎是从生长单纯疱疹病毒的绿猴肾细胞中提取的。在未感染的人皮肤成纤维细胞中也显示出相同的抗原活性。我们的结论是，同性恋男性的ITP伴随着针对血小板抗原25,000道尔顿的血清抗体。该抗原的性质及血清抗体与ITP的关系有待进一步研究。[J] .中华医学杂志，1985;33(3):1375 - 1380。
A syndrome of isolated immune thrombocytopenic purpura (ITP) has recently been described in homosexual men. We have identified an antiplatelet antibody in the serum of 29 of 30 homosexual men with isolated ITP. The antibody binds to a platelet membrane antigen of 25,000 daltons, and binding is effected by the F(ab)2portion of the immunoglobulin. Similar antibody activity was not detected in serum from 30 nonhomosexual patients with either ITP or nonimmune thrombocytopenia. The 25,000-dalton antigen was not found on other hematopoietic cells, and it was distinct from the core protein of the AIDS-associated retrovirus. In contrast, serum antibody reacted with a 25,000-dalton antigen associated with cultured herpes simplex virus Types I and II. In these experiments the antigen appeared to be derived from green-monkey kidney cells in which the herpes simplex viruses were grown. Identical antigenic activity was also demonstrated in uninfected human skin fibroblasts. We conclude that ITP in homosexual men is accompanied by a serum antibody directed against a platelet antigen of 25,000 daltons. The nature of the antigen and the relation of the serum antibody to ITP require further study. (N Engl J Med 1985; 313:1375–80.)