Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neurons
Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neurons
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DOI：
10.1016/j.neubiorev.2006.03.003
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发表时间：
2007-01-01
影响因子：
8.2
通讯作者：
Fisone, Gilberto
中科院分区：
文献类型：
--
作者：
Borgkvist, Anders;Fisone, Gilberto
背侧和腹侧纹状体的中等多棘神经元（MSNs）活动的改变会导致运动表现的变化，其范围从运动活动的快速增加或减少，到运动行为的长期改变。在背侧纹状体中，MSNs可根据其与黑质网状部（SNpr）和苍白球内侧部（GPi）的连接组织来区分，而黑质网状部和苍白球内侧部反过来又控制丘脑皮质神经元。大约一半的MSNs直接投射到SNpr和GPi，它们的激活导致丘脑皮质神经元去抑制并增加运动活动。另一亚群的MSNs间接连接到SNpr和GPi，当被激活时会促进对丘脑皮质神经元的抑制，从而减少运动活动。32 kDa的多巴胺和环磷腺苷酸调节的磷蛋白（DARPP - 32）是环磷腺苷酸信号通路的调节剂，在MSNs中高度表达。这篇综述讨论了精神活性物质对纹状体投射神经元特定群体中DARPP - 32的调节及其在短期和长期运动反应中的作用。（c）2006爱思唯尔有限公司。保留所有权利。
Changes in activity of the medium spiny neurons (MSNs) of dorsal and ventral striatum result in alterations of motor performance, ranging from rapid increases or decreases in locomotor activity, to long-term modifications of motor behaviours. In the dorsal striatum, MSNs can be distinguished based on the organization of their connectivity to substantia nigra pars reticulata (SNpr) and internal segment of the globus pallidus (GPi), which, in turn, control thalamocortical neurons. Approximately half of the MSNs project directly to SNpr and GPi, their activation leading to disinhibition of thalamocortical neurons and increased motor activity. The other subpopulation of MSNs connects to SNpr and GPi indirectly and when activated promotes inhibition of thalamocortical neurons, thereby reducing motor activity. The dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) is a modulator of the cAMP signalling pathway, highly expressed in MSNs. This review discusses the regulation of DARPP-32 exerted by psychoactive substances in specific populations of striatal projection neurons and its involvement in short- and long-term motor responses. (c) 2006 Elsevier Ltd. All rights reserved.