IODINE ATOM TRANSFER ADDITION-REACTIONS WITH ALKYNES .2. ALPHA-IODOCARBONYLS
IODINE ATOM TRANSFER ADDITION-REACTIONS WITH ALKYNES .2. ALPHA-IODOCARBONYLS
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DOI：
10.1016/s0040-4020(01)86551-0
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发表时间：
1991-08-05
期刊：
影响因子：
2.1
通讯作者：
ZIEGLER, C
中科院分区：
文献类型：
--
作者：
CURRAN, DP;KIM, D;ZIEGLER, C
1-度碘酯、酮和腈在与烷基取代（亲核）炔烃的原子转移加成反应中能顺利反应，但 3-度碘酯更倾向于与酯取代（亲电）炔烃加成。 这些原子转移加成物适用于制备自由基易位反应的前体以及附加β-内酰胺侧链。
1-degrees-Iodo esters, ketones, and nitriles react smoothly in atom transfer addition reactions with alkyl-substituted (nucleophilic) alkynes, but a 3-degrees-iodoester prefers to add to ester-substituted (electrophilic) alkynes. These atom transfer additions are suited for preparing precursors for radical translocation reactions as well for appending beta-lactam side chains.