Mitigating the impact of mechanisms causing neuronal degeneration.
Mitigating the impact of mechanisms causing neuronal degeneration.
复制标题
减轻引起神经元变性的机制的影响。
DOI：
10.1002/nep3.41
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Boltze,Johannes
中科院分区：
文献类型：
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作者：
Ji,Xuming;Walczak,Piotr;Boltze,Johannes
原发性和继发性神经变性是许多中枢神经系统（CNS）疾病的病理标志。虽然许多机制导致神经退行性变是很好的理解，以前的方法，旨在提供保护神经退行性变往往是徒劳的。一个潜在的解释可能是最近的研究发现了导致神经退行性变的其他病理机制。因此，简单地靶向单一神经退行性机制可能仅具有较小的治疗影响。解决多种神经退行性机制可能是一种更可行的策略。此外，恢复失去的脑组织是一项非常复杂的奋进。1尽管使用生物相容性支架和水凝胶取得了一些初步进展，2但迄今为止，有意义的修复目标仍然难以实现。因此，必须对神经退行性机制进行详细和全面的了解，以不断改进我们的策略，减轻其对CNS疾病的影响。这对于中风、阿尔茨海默病和血管性痴呆等重大疾病尤其重要，因为它们是全球严重残疾、认知功能障碍、生活质量下降和患者死亡率的主要原因。这一期的《神经保护》介绍了原始的贡献和评论，为原发性和继发性神经退行性变的机制提供了新的见解。这些可能代表新方法提供神经保护的治疗靶点。这篇社论强调了在本期《神经保护》杂志上发表的文章中发现的一些有趣的方面。
Primary and secondary neurodegeneration is a pathological hallmark of numerous central nervous system (CNS) disorders. Although many mechanisms leading to neurodegeneration are well understood, previous approaches aiming at providing protection from neurodegeneration were often futile. A potential explanation may be that recent research discovered additional pathomechanisms leading to neurodegeneration. Thus, simply targeting single neurodegenerative mechanisms may only have minor therapeutic impact. Addressing multiple neurodegenerative mechanisms may be a more viable strategy. Moreover, the restoration of lost brain tissue turned out to be a very complex endeavor. 1 Despite making some initial progress with the use of biocompatible scaffolds and hydrogels, 2 the goal of meaningful restoration remains elusive so far. It is therefore essential to obtain a detailed and holistic understanding of neurodegenerative mechanisms to continuously improve our strategies to mitigate their impact in CNS disorders. This is particularly important for major diseases such as stroke, Alzheimer's disease, and vascular dementia, as they are leading contributors to severe disabilities, cognitive dysfunction, loss of quality of life, and patient mortality worldwide. This issue of Neuroprotection presents original contributions and reviews providing novel insights into mechanisms of primary and secondary neurodegeneration. Those may represent therapeutic targets for novel approaches to provide neuroprotection. This editorial highlights some intriguing aspects found within the articles published in the current issue of Neuroprotection.