Sustainable cutaneous gene delivery
Sustainable cutaneous gene delivery
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DOI：
10.1038/nbt1297-1388
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发表时间：
1997-12-01
影响因子：
46.9
通讯作者：
Khavari, PA
中科院分区：
文献类型：
--
作者：
Deng, H;Lin, Q;Khavari, PA
将基因持久地输送到人体皮肤对于持久纠正人类遗传性皮肤病是必要的。然而，目前的皮肤基因传递策略仅实现了短暂的基因表达，通常仅在一小部分组织细胞内。由于再生表皮组织中治疗基因表达的丧失，最近无法维持人类遗传性皮肤病的表型校正，这凸显了当前的局限性。为了克服这个问题，我们已经产生了基因传递载体，可以在体内人体皮肤组织中产生更持久的基因传递。
Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic correction of human genetic skin disease due to loss of therapeutic gene expression in regenerated epidermal tissue has highlighted this current limitation. In an effort to surmount this problem, we have generated gene delivery vectors that produce more durable gene delivery in human skin tissue in vivo.