A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression
A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression
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DOI：
10.1017/s1461145707007833
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发表时间：
2008-03-01
影响因子：
4.8
通讯作者：
Fregni, Felipe
中科院分区：
文献类型：
--
作者：
Boggio, Paulo S.;Rigonatti, Sergio P.;Fregni, Felipe
初步研究结果表明，经颅直流电刺激(Tdcs)可以起到抗抑郁作用。我们试图在一项平行分组的双盲临床试验中进一步验证这一点，40名重度抑郁症患者被随机分成三组：左侧背外侧前额叶皮质TDC(活动组)、枕叶皮质TDCs(活动对照组-枕叶)和假TDC(安慰剂对照组-SHAM)。在2wk期间应用tdcs共10次。采用汉密尔顿抑郁量表(HDRS)和贝克抑郁量表(BDI)对心境进行盲评。该治疗耐受性良好，副作用最小，在所有治疗组中平均分布。我们发现，与枕部[HDRS降低21.3%(+/-12.9%)]和假TDC[HDRS降低10.4%(+/-36.6%)]相比，DLPFC tDCS[HDRS降低40.4%(+/-25.8%)]后抑郁评分的降低明显更大。DLPFC组在治疗结束后1个月仍有TDCs的益处。我们的发现支持进一步研究这种新的潜在治疗方法--tdcs--治疗重度抑郁症的效果。
Preliminary findings suggest that transcranial direct current stimulation (tDCS) can have antidepressant effects. We sought to test this further in a parallel-group, double-blind clinical trial with 40 patients with major depression, medication-free randomized into three groups of treatment: anodal tDCS of the left dorsolateral prefrontal cortex (active group-'DLPFC'); anodal tDCS of the occipital cortex (active control group-'occipital') and sham tDCS (placebo control group-'sham'). tDCS was applied for 10 sessions during a 2-wk period. Mood was evaluated by a blinded rater using the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). The treatment was well tolerated with minimal side-effects that were distributed equally across all treatment groups. We found significantly larger reductions in depression scores after DLPFC tDCS [HDRS reduction of 40.4 % (+/-25.8%)] compared to occipital [HDRS reduction of 21.3 % ( +/-12.9%)] and sham tDCS [HDRS reduction of 10.4 % (+/-36.6%)]. The beneficial effects of tDCS in the DLPFC group persisted for 1 month after the end of treatment. Our findings support further investigation on the effects of this novel potential therapeutic approach - tDCS - for the treatment of major depression.