Serum CA-125 in relation to adnexal dysplasia and cancer in women at hereditary high risk of ovarian cancer
Serum CA-125 in relation to adnexal dysplasia and cancer in women at hereditary high risk of ovarian cancer
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DOI：
10.1200/jco.2006.06.7884
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发表时间：
2007-04-10
影响因子：
45.3
通讯作者：
Verheijen, Rene H. M.
中科院分区：
文献类型：
--
作者：
Hermsen, Brenda B. J.;von Mensdorff-Pouilly, Silvia;Verheijen, Rene H. M.
目的血清CA-125水平常作为卵巢癌复发的指标。然而，其预测肿瘤病变的价值是未知的。本研究的目的是调查是否CA-125浓度是指示附件发育不良和癌症的妇女在遗传性高风险的卵巢/输卵管cancer.Patients和MethodsCA-125获得424名妇女在遗传性高风险的卵巢/输卵管癌参加自由大学医学中心（阿姆斯特丹，荷兰）1993年和2005年之间。在因诊断性（n = 9）或预防性（n = 89）原因接受附件手术的女性中，检测了手术前第二次至最后一次（n = 64）和最后一次（n = 98）访视时获得的血清样本。以370例年龄相匹配的健康妇女血清为对照。
PurposeSerum CA-125 level is commonly used as indicator for ovarian cancer recurrence. However, its value for the prediction of neoplastic lesions is unknown. The aim of this study was to investigate whether CA-125 concentrations are indicative of adnexal dysplasia and cancer in women at hereditary high risk of ovarian/tubal cancer.Patients and MethodsCA-125 was obtained from 424 women at hereditary high risk of ovarian/tubal cancer attending the VU University Medical Center ( Amsterdam, the Netherlands) between 1993 and 2005. Serum samples obtained at the second-to-last ( n = 64) and last ( n = 98) visit before surgery were tested in women who underwent adnexal surgery for diagnostic ( n = 9) or prophylactic ( n = 89) reasons. Serum samples obtained from 370 age-matched healthy women were used as controls.ResultsBoth the absolute value ( P