Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model
Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model
复制标题
肺动脉高压死亡率：2015年欧洲肺动脉高压指南风险分层模型预测
DOI：
10.1183/13993003.00740-2017
复制
发表时间：
2017-08-01
影响因子：
24.3
通讯作者：
Gruenig, Ekkehard
中科院分区：
文献类型：
--
作者：
Hoeper, Marius M.;Kramer, Tilmann;Gruenig, Ekkehard
2015年欧洲肺动脉高压（PH）指南提出了肺动脉高压（PAH）患者的风险分层策略。低、中和高风险分层分别由估计的1年死亡率风险10%定义。该风险评估策略有待验证。我们分析了COMPERA（一项基于欧洲的PH登记研究，新启动肺动脉高压治疗的比较性、前瞻性登记研究）中新诊断PAH患者的数据。应用欧洲PH指南提出的风险评估策略的简化版本，使用以下变量：世界卫生组织功能分级，6分钟步行距离，脑钠肽或其N-末端片段，右心房压力，心脏指数和混合静脉血氧饱和度。死亡率在三个风险层之间有显著差异（p
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH). Low-, intermediate-and high-risk strata are defined by estimated 1-year mortality risks of 10%, respectively. This risk assessment strategy awaits validation.We analysed data from patients with newly diagnosed PAH enrolled into COMPERA (Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension), a European-based PH registry. An abbreviated version of the risk assessment strategy proposed by the European PH guidelines was applied, using the following variables: World Health Organization functional class, 6-min walking distance, brain natriuretic peptide or its N-terminal fragment, right atrial pressure, cardiac index and mixed venous oxygen saturation.Data from 1588 patients were analysed. Mortality rates were significantly different between the three risk strata (p