Volatile Metabolites and Decomposition Products of Halothane In Man
Volatile Metabolites and Decomposition Products of Halothane In Man
复制标题
人体氟烷的挥发性代谢物和分解产物
作者：
J. Sharp;J. Trudell;E. N. Cohen
存在两种挥发性氟烷代谢物，2-氯-1，1，1-三氟乙烷（CF 3CH 2Cl）和2-氯-1，1-二氟乙烯（CF2 CHCl），以及代谢物分解产物2-溴-2-氯-1，1-二氟乙烯用气相色谱-质谱联用技术对16例氟烷麻醉病人非重复呼吸时呼出气中CF_2CBrCl进行了检测，半封闭和全封闭麻醉回路。相对于所用的麻醉回路，未发现CF 3CH 2Cl和CF2 CHCl的浓度存在显著差异。在使用非再呼吸回路（Bain）麻醉的患者的呼出气体中无法识别出CF 2CBrCl，但在从半封闭和完全封闭回路中回收的气体中均存在CF 2CBrCl。在完全闭合回路再呼吸条件下，CF2 CBrCl的浓度增加到4-5 ppm，表明苏打石灰对氟烷的显著分解。两种代谢产物和代谢产物的形成的可能途径，以及这些发现的临床意义。
The presence of two volatile halothane metabolites, 2-chloro-1,1,1-trifluoroethane (CF3CH2Cl) and 2-chloro-1,1-difluoroethylene (CF2CHCl), and a metabolite-decomposition product, 2-bromo-2-chloro-1,1-difluoroethylene (CF2CBrCl), were identified by gas chromatography—maas spectrometry in exhaled gases of 16 patients anesthetized with halothane in nonrebreathing, semiclosed and totally closed anesthesia circuits. No significant differences in concentrations of CF3CH2Cl and CF2CHCl were found relative to the anesthesia circuits used. CF2CBrCl could not be identified in the expired gases of patients anesthetized with a nonrebreathing circuit (Bain), but was present in gases recovered from both semiclosed and totally closed circuits. Under totally closed-circuit rebreathing conditions, the concentration of CF2CBrCl increased to 4–5 ppm, indicating significant breakdown of halothane by the soda lime. Possible pathways for formation of the two metabolites and the metabolite—decomposition product are presented, as well as clinical implications of these findings.