PDZ adaptors : their regulation of epithelial transporters and involvement in human disease
PDZ adaptors : their regulation of epithelial transporters and involvement in human disease
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PDZ接头：它们对上皮转运蛋白的调节和参与人类疾病
DOI：
10.1002/jps.22575
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kato Y
中科院分区：
文献类型：
--
作者：
Sugiura T;Shimizu T;Kijima A;Minakata S;Kato Y
体内的稳态至少部分地通过控制膜渗透性的机制来维持，从而用于控制必需物质（例如，营养物）和不需要的物质的流出（例如，外源性物质和代谢物）。各种转运蛋白在这种双向转运中发挥着重要作用，但对它们在质膜上的组织方式知之甚少。蛋白质-蛋白质相互作用可能起着关键作用：上皮细胞中的几种转运蛋白与所谓的衔接蛋白相互作用，衔接蛋白是膜锚定的，与转运蛋白和其他膜蛋白相互作用。虽然大多数关于转运蛋白-衔接子相互作用的证据都是在体外获得的，但最近的研究表明衔接子介导的转运蛋白调节确实发生在体内，并且可能与人类疾病有关。因此，蛋白质-蛋白质相互作用不仅与大分子复合物的形成有关，而且还参与各种细胞事件，并且可以通过在质膜上形成转运蛋白网络来为转运蛋白提供额外的功能。Kato和Tsuji（2006年）先前综述了外源性转运蛋白与PSD 95/Dlg/ZO 1（PDZ）衔接子之间的相互作用。Eur J Pharm Sci 27：487-500）;本综述集中于关于PDZ衔接子作为转运蛋白网络的调节剂及其在人类疾病中的潜在作用的最新发现。© 2011 Wiley-Liss公司。和American Pharmacologist Association J Pharm Sci 100：3620-3635，2011
Homeostasis in the body is at least partially maintained by mechanisms that control membrane permeability, and thereby serve to control the uptake of essential substances (e.g., nutrients) and the efflux of unwanted substances (e.g., xenobiotics and metabolites) in epithelial cells. Various transporters play fundamental roles in such bidirectional transport, but little is known about how they are organized on plasma membranes. Protein–protein interactions may play a key role: several transporters in epithelial cells interact with the so-called adaptor proteins, which are membrane anchored and interact with both transporters and other membranous proteins. Although most of the evidences for transporter–adaptor interaction has been obtainedin vitro, recent studies suggest that adaptor-mediated transporter regulation does occurin vivoand could be relevant to human diseases. Thus, protein–protein interaction is not only associated with the formation of macromolecular complexes but is also involved in various cellular events, and may provide transporters with additional functionality by forming transporter networks on plasma membranes. Interactions between xenobiotic transporters and PSD95/Dlg/ZO1 (PDZ) adaptors were previously reviewed by Kato and Tsuji (2006. Eur J Pharm Sci 27:487–500); the present review focuses on the latest findings about PDZ adaptors as regulators of transporter networks and their potential role in human diseases. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3620–3635, 2011