VITAMIN-E AND BIOLOGICAL ANTIOXIDANT THEORY
VITAMIN-E AND BIOLOGICAL ANTIOXIDANT THEORY
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DOI：
10.1111/j.1749-6632.1972.tb27853.x
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发表时间：
1972-01-01
影响因子：
5.2
通讯作者：
GREEN, J
中科院分区：
文献类型：
--
作者：
GREEN, J
尽管维生素E已经被持续研究了近50年，但关于它的生物学作用仍然存在分歧。一种主要的理论已经被提出来解释和明显地关联关于这种维生素的大多数已知的营养和生化事实：抗氧化剂理论。根据这一理论，维生素E(a-生育酚)在动物的脂肪系统中作为抗氧化剂发挥作用。该理论表明，组织中的不饱和脂肪不断受到自由基的攻击，这些自由基可能是随机产生的，也可能是在代谢反应中产生的，在氧气存在的情况下，它们会被过氧化。组织脂质过氧化被认为与不饱和脂肪在VIM中氧化的自氧化过程在动力学和力学上是相同的。根据这一理论，α-生育酚在体内通过与自由基反应来发挥作用，从而抑制组织过氧化过程。如果没有足够的维生素E，脂质的过氧化就会变得广泛和不受控制，从而导致细胞内膜、酶和某些代谢物的广泛损害。因此，总而言之，维生素E缺乏对动物的所有不同影响都被认为是次要的，源于一个主要过程--脂质过氧化。一些工作人员认为维生素E具有更特殊的生化作用。本文的目的是批判性地讨论抗氧化剂的理论及其依据，以便更好地理解其与维生素E功能的相关性。
Although vitamin E has been under continuous investigation for nearly five decades, there is still disagreement as to its biological role. One major theory has been put forward to explain and apparently correlate most of the known nutritional and biochemical facts about this vitamin: the antioxidant theory. According to this theory, vitamin E (a-tocopherol) functions in lipid systems in the animal as an antioxidant. The theory suggests that tissue unsaturated lipids are continually under attack by free radicals, which may be either of random origin or produced in metabolic reactions, and that in the presence of oxygen they become peroxidized. Tissue lipid peroxidation is considered to be identical, kinetically and mechanistically, with the autoxidation process by which unsaturated fats can become oxidized in vim. According to the theory, a-tocopherol functions in vivo by reacting with free radicals and so inhibiting the tissue peroxidation process. If sufficient vitamin E is not present, the peroxidation of lipids becomes extensive and uncontrolled, so leading to widespread damage to intracellular membranes, enzymes, and certain metabolites. In summary, therefore, all the diverse effects of vitamin E deficiency in animals are considered to be secondary, stemming from one primary process, lipid peroxidation.Some workers consider that vitamin E has a more specific biochemical role. It is the purpose of this paper to discuss critically the antioxidant theory and the evidence on which it is based, in order to arrive at a better understanding of its relevance to the function of vitamin E.