Withanolides with Antibacterial Activity from Nicandra john-tyleriana
Withanolides with Antibacterial Activity from Nicandra john-tyleriana
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DOI：
10.1021/np500824f
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发表时间：
2015-02-01
影响因子：
5.1
通讯作者：
Nicotra, Viviana E.
中科院分区：
文献类型：
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作者：
Gutierrez Nicolas, Fatima;Reyes, Guadalupe;Nicotra, Viviana E.
从烟草（Nicandra john-tyleriana）地上部分分离得到11个新的睡茄内酯（1-11）。这些睡茄内酯中有五种具有未修饰的骨架（1-5），两种是acnistins（6，7），四种是withajardins（8-11）。这些新的分离物充分利用光谱技术（包括多维NMR）和质谱的组合进行了表征。评价了所有化合物对芽孢杆菌属、肠球菌属、埃希氏菌属、李斯特菌属、假单胞菌属和葡萄球菌属菌株的抗菌活性。
Eleven new withanolides (1-11) were isolated and characterized from the aerial parts of Nicandra john-tyleriana. Five of these withanolides have an unmodified skeleton (1-5), two are acnistins (6, 7), and four are withajardins (8-11). These new isolates were fully characterized using a combination of spectroscopic techniques (including multidimensional NMR) and mass spectrometry. All compounds were evaluated for their antibacterial activity against Bacillus, Enterococcus, Escherichia, Listeria, Pseudomonas, and Staphylococcus strains.