Primary cortical folding in the human newborn:: an early marker of later functional development
Primary cortical folding in the human newborn:: an early marker of later functional development
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DOI：
10.1093/brain/awn137
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发表时间：
2008-08-01
期刊：
影响因子：
14.5
通讯作者：
Hueppi, P. S.
中科院分区：
文献类型：
--
作者：
Dubois, J.;Benders, M.;Hueppi, P. S.
在人类大脑中，皮质回和脑沟的形态复杂多样，可能反映了病理功能，并在某些发育和神经精神障碍中观察到特定的异常。由于皮质折叠发生在大脑发育的早期，这些结构异常可能在功能性症状出现之前很久就出现了。到目前为止，在子宫内或出生后发育过程中导致这种卷曲模式变化的确切机制仍不清楚。在这里，我们比较了45名经历不同宫内环境的早产儿的活体脑发育情况：22名正常单胎、12名双胞胎和11名患有宫内生长受限(IUGR)的新生儿。使用磁共振成像(MRI)和专用的后处理工具，我们调查了出生时皮质形成的早期障碍，在对卷曲出现至关重要的发育期(胎龄2636周)，并确定了脑沟发育的早期内表型。我们发现双胞胎具有延迟但协调的成熟，表面和硫化指数比单胎低，而IUGR新生儿的回旋与正常发育轨迹不一致，表面相对于硫化指数的减少比正常新生儿更明显。此外，我们还表明，出生时对大脑的这些结构测量可以预测婴儿在足月相同年龄时的结局，因为基于MRI的脑体积和神经行为发育通过早产儿行为评估(APIB)进行评估。
In the human brain, the morphology of cortical gyri and sulci is complex and variable among individuals, and it may reflect pathological functioning with specific abnormalities observed in certain developmental and neuropsychiatric disorders. Since cortical folding occurs early during brain development, these structural abnormalities might be present long before the appearance of functional symptoms. So far, the precise mechanisms responsible for such alteration in the convolution pattern during intra-uterine or post-natal development are still poorly understood. Here we compared anatomical and functional brain development in vivo among 45 premature newborns who experienced different intra-uterine environments: 22 normal singletons, 12 twins and 11 newborns with intrauterine growth restriction (IUGR). Using magnetic resonance imaging (MRI) and dedicated post-processing tools, we investigated early disturbances in cortical formation at birth, over the developmental period critical for the emergence of convolutions (2636 weeks of gestational age), and defined early endophenotypes of sulcal development. We demonstrated that twins have a delayed but harmonious maturation, with reduced surface and sulcation index compared to singletons, whereas the gyrification of IUGR newborns is discordant to the normal developmental trajectory, with a more pronounced reduction of surface in relation to the sulcation index compared to normal newborns. Furthermore, we showed that these structural measurements of the brain at birth are predictors of infants outcome at term equivalent age, for MRI-based cerebral volumes and neurobehavioural development evaluated with the assessment of preterm infants behaviour (APIB).