A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection
A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection
复制标题
DOI：
10.1126/science.aah4563
复制
发表时间：
2017-03-10
期刊：
影响因子：
56.9
通讯作者：
Faye, Ingrid
中科院分区：
文献类型：
--
作者：
Emami, S. Noushin;Lindberg, Bo G.;Faye, Ingrid
疟疾感染使人类比未感染的人对广义冈比亚按蚊更具吸引力。其机制尚不清楚。我们发现恶性疟原虫产生的类异戊二烯前体（E）-4-羟基-3-甲基-丁-2-烯焦磷酸（HMBPP）影响A。冈比亚湾L.吸血和进食行为以及对感染的易感性。HMBPP通过触发人红细胞增加CO2、醛类和单萜类的释放而间接起作用，这些物质一起增强媒介吸引力并刺激媒介进食。当在血餐中提供时，HMBPP调节神经、抗疟和卵子基因转录而不影响蚊子存活或繁殖力;在恶性疟原虫感染的血餐中，孢子生殖增加。
Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s. l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.