DIMINISHED INSULIN SENSITIVITY AND INCREASED INSULIN-RESPONSE IN NONOBESE, NONDIABETIC MEXICAN-AMERICANS
DIMINISHED INSULIN SENSITIVITY AND INCREASED INSULIN-RESPONSE IN NONOBESE, NONDIABETIC MEXICAN-AMERICANS
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DOI：
10.1016/0026-0495(90)90130-5
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发表时间：
1990-08-01
影响因子：
9.8
通讯作者：
BERGMAN, RN
中科院分区：
文献类型：
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作者：
HAFFNER, SM;STERN, MP;BERGMAN, RN
胰岛素敏感性降低和胰岛素反应性降低在非胰岛素依赖型糖尿病（NIDDM）发生中的作用仍存在争议。非糖尿病的NIDDM高危人群，包括皮马印第安人和墨西哥裔美国人，其特征是肥胖和高胰岛素血症，相对于非糖尿病的低风险白色人群。然而，尚不清楚高风险群体中胰岛素敏感性降低在多大程度上反映了肥胖本身或这些群体的固有特征。在10名非肥胖、血糖正常的墨西哥裔美国人中测定胰岛素敏感性和分泌（平均体重指数[BMI]，23.8 kg/m2）和11名血糖正常的非西班牙裔白人（平均BMI，22.5 kg/m2），使用静脉葡萄糖耐量试验（IVGTT）和Bergman等人的最小模型方法。年龄，BMI，皮褶总和，两个种族的腰围与臀围之比（WHR）相似。与非西班牙裔白人相比，墨西哥裔美国人的胰岛素敏感性降低（4.06 . ±. 0.72墨西哥裔美国人v 7.56 .+-. 1.13在非西班牙裔白人中，P = 0.017）。墨西哥裔美国人的C肽和胰岛素曲线下面积显著大于非西班牙裔白人（P <0.01），表明前者的胰岛素分泌量更大。这项研究为年轻、非肥胖、血糖正常的墨西哥裔美国人提供了胰岛素敏感性降低和胰岛素反应增加的证据。
The contributions of diminished insulin sensitivity and decreased insulin response to the development of non-insulin-dependent diabetes mellitus (NIDDM) remain controversial. Nondiabetics in high-risk populations for NIDDM, including Pima Indians and Mexican Americans, are characterized by obesity and hyperinsulinemia relative to nondiabetics in the lower-risk white population. However, it is not clear to what extent diminished insulin sensitivity in the high-risk groups reflects obesity per se or is an inherent characteristic of these groups. Insulin sensitivity and secretion were determined in 10 nonobese, normoglycemic Mexican Americans (mean body mass index [BMI], 23.8 kg/m2) and 11 normoglycemic non-Hispanic whites (mean BMI, 22.5 kg/m2) using the intravenous glucose tolerance test (IVGTT) and the minimal model approach of Bergman et al. Age, BMI, sum of skinfolds, and the ratio of waist-to-hip circumference (WHR) were similar in both ethnic groups. Mexican Americans had decreased insulin sensitivity compared with non-Hispanic whites (4.06 .+-. 0.72 in Mexican Americans v 7.56 .+-. 1.13 in non-Hispanic whites, P = .017). The areas under the C-peptide and insulin curves were significantly greater in Mexican Americans than in non-Hispanic whites (P < .01), suggesting greater insulin secretion in the former. This study provides evidence for diminished insulin sensitivity and incresaed insulin response in young, nonobese, normoglycemic Mexican Americans.