Neurodevelopmental outcomes following necrotizing enterocolitis
Neurodevelopmental outcomes following necrotizing enterocolitis
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DOI：
10.1016/j.siny.2018.08.005
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发表时间：
2018-12-01
影响因子：
3
通讯作者：
Ramel, Sara
中科院分区：
文献类型：
--
作者：
Hickey, Marie;Georgieff, Michael;Ramel, Sara
坏死性小肠结肠炎（NEC）是一种主要影响早产儿的胃肠道急症，与神经发育不良的风险增加有关。NEC通常发生在神经系统快速动态发育时期，此时大脑特别容易受到损伤和营养缺乏。NEC后神经发育障碍的发病机制可能是多因素的，营养和非营养因素都在起作用。确保早期发现和干预损伤的后续测试对于优化NEC后的神经发育结果至关重要。对NEC患者进行多方面的随访是必要的，包括密切监测生长、连续发育评估、神经系统检查、听力和视力测试以及神经影像学检查。需要进一步的研究来了解NEC后神经发育障碍的发病机制，确定更有针对性的随访测试，并发现旨在优化NEC后神经发育结局的干预措施。
Necrotizing enterocolitis (NEC), a gastrointestinal emergency predominantly affecting premature infants, is associated with increased risk for poor neurodevelopmental outcomes. NEC often strikes during a period of rapid and dynamic neurologic development when the brain is particularly vulnerable to insults and nutrient deficits. The pathogenesis of neurodevelopmental impairment following NEC is likely multifactorial, with both nutritional and non-nutritional factors at play. Follow-up testing that ensures early detection and intervention for impairments is crucial to optimize neurodevelopmental outcomes following NEC. A multifaceted approach to follow-up after NEC is necessary, with close monitoring of growth, serial developmental assessments, neurologic examinations, hearing and vision testing and neuroimaging. Further research is needed to understand the pathogenesis of neurodevelopmental impairment following NEC, to identify more targeted follow-up tests, and to discover interventions aimed at optimizing neurodevelopmental outcomes following NEC.