Retrograde facilitation of verbal memory by trihexyphenidyl in healthy elderly with and without the APOE epsilon4 allele.
Retrograde facilitation of verbal memory by trihexyphenidyl in healthy elderly with and without the APOE epsilon4 allele.
复制标题
苯海索对有或没有 APOE epsilon4 等位基因的健康老年人的言语记忆的逆行促进作用。
DOI：
10.1016/j.euroneuro.2010.03.004
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Sidtis,JohnJ
中科院分区：
文献类型：
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作者：
Pomara,Nunzio;Yi,Linlin;Belzer,Ken;Facelle,ThomasM;Willoughby,LisaM;Sidtis,JohnJ
在24名健康老年受试者中研究了急性口服苯海索（一种优先的毒蕈碱M1受体拮抗剂，可损害新的学习）前学习信息的逆行易化（RF）。并对该抗胆碱能药物诱发的RF与APOE ε4等位基因的关系进行了研究。使用Buschke选择性提醒试验在给药前和给药后1、2.5和5小时测定苯海索（1 mg和2 mg）的急性不良反应。在第五小时神经心理学评估结束时对药物前词语的回忆（会话结束回忆）是主要兴趣。与安慰剂相比，服用2mg苯海索后，给药前研究的单词回忆更好，并且这种RF效应不受APOE ε4等位基因的影响。服用2 mg苯海索后，对用药前的词语记忆更好，与该剂量的更大遗忘效应相关。我们的研究结果表明，RF引起的苯海索是有关的药物的顺行性遗忘的影响，并导致部分从药物引起的追溯干扰的减少。
Retrograde facilitation (RF) of information learned prior to acute oral administration of trihexyphenidyl, a preferential muscarinic M1 receptor antagonist which impairs new learning, was studied in 24 healthy elderly subjects. The relationship between the RF induced by this anticholinergic drug and the APOE ε4 allele was also examined. Acute adverse performance effects of trihexyphenidyl (1- and 2mg) were determined using the Buschke Selective Reminding Test administered pre-drug and at 1, 2.5, and 5h post-drug. Recall of pre-drug words at the end of the fifth hour neuropsychological assessment (end-of-session recall) was of primary interest. Words studied before drug administration were better recalled following 2mg trihexyphenidyl compared to placebo, and this RF effect was not affected by the APOE ε4 allele. Better recall of pre-drug words following 2-mg trihexyphenidyl was associated with a greater amnestic effect of this dose. Our findings demonstrated that RF induced by trihexyphenidyl was related to anterograde amnestic effects of the drug and resulted in part from drug-induced reduction of retroactive interference.