A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis
A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis
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DOI：
10.1136/bjo.87.10.1235
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发表时间：
2003-10-01
影响因子：
4.1
通讯作者：
Srinivasan, M
中科院分区：
文献类型：
--
作者：
Prajna, NV;John, RK;Srinivasan, M
目的：比较2%益康唑与5%纳他霉素治疗真菌性角膜炎的疗效。方法：在印度马杜赖Aravind眼科护理系统的角膜服务中心，采用2% econazole或5% natamycin作为两个治疗组，对出现培养阳性真菌性角膜炎的患者进行随机临床试验。结果：116名患者被招募，112名患者继续参与研究。两组在基线或最终访视成功（定义为愈合或溃疡愈合）方面无显著差异（p = 0.79）。结论：2%益康唑与5%纳他霉素治疗真菌性角膜炎同样有效。
Aim: To compare 2% econazole and 5% natamycin in the management of fungal keratitis.Methods: A randomised clinical trial was performed using 2% econazole or 5% natamycin as the two treatment arms on patients presenting with culture positive fungal keratitis to the cornea service at Aravind Eye Care System, Madurai, India.Results: 116 patients were recruited, and 112 continued in the study. There were no significant differences between the two arms at baseline or for success ( defined as a healed or healing ulcer) at final visit ( p = 0.79).Conclusions: 2% Econazole appears to be as effective as 5% natamycin for the management of fungal keratitis.