Animal models of obesity in rodents. An integrative review
Animal models of obesity in rodents. An integrative review
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DOI：
10.1590/s0102-865020160120000010
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发表时间：
2016-12-01
期刊：
影响因子：
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通讯作者：
Guimarães, Rita de Cássia Avellaneda
中科院分区：
文献类型：
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作者：
Fernandes, Melina Ribeiro;Lima, Nayara Vieira de;Guimarães, Rita de Cássia Avellaneda
目得：对用于肥胖症的啮齿动物主要动物疾病模型进行综合性综述。方法：研究在CAPES Portal数据库中进行，使用以下关键词“肥胖症动物模型，饮食和啮齿动物”，2010年至2016年期间发表。结果：近6年来发表的文献较多，其中大鼠10只，小鼠10只。雄性动物（n = 18）和年龄大于21天（n = 17）的选择显示了一个主要亮点。超过5周的随访期（n = 18）是最适用的。高脂饮食是最常用的研究（n = 18）。结论：雄性啮齿动物仍然被认为是最常用的实验研究中诱导肥胖的物种，也发现了年龄的变化，以实验开始。大部分是随访时间研究沿着高脂肪饮食的使用。
PURPOSE: To perform an integrative review of the main animal disease models in rodents used for obesity.METHODS: Research was conducted in the CAPES Portal database using the following keywords "obesity animal models, diet and rodents", published between the years 2010 to 2016. We found 108 articles, of which 19 were selected and analyzed in full for this study.RESULTS: Larger part of publications occurred in the last 6 years, the rats (n = 10) were used in the same proportion mice (n = 10). The choice of male animals (n = 18) and age greater than 21 days (n = 17) showed a major highlight. The greater than 5 week follow-up period (n = 18) was the most applied. A High Fat Diet was the most used in studies (n = 18).CONCLUSIONS: Male rodents continue to be considered the species most used in experimental studies to induce obesity, also was found variations of age to the beginning of the experiment. For the most part are follow-up time studies along with the use of High Fat Diet.