The Influence of Mucin-Based Artificial Saliva on Properties of Polycaprolactone and Polylactide
The Influence of Mucin-Based Artificial Saliva on Properties of Polycaprolactone and Polylactide
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DOI：
10.3390/polym11111880
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发表时间：
2019-11-01
期刊：
影响因子：
5
通讯作者：
Bucki, Robert
中科院分区：
文献类型：
--
作者：
Lysik, Dawid;Mystkowska, Joanna;Bucki, Robert
聚己内酯（PCL）和聚乳酸（PLA）是两种最常见的可生物降解的聚合物，具有潜在的口腔应用。这两种聚合物在人体内主要发生缓慢的水解降解。然而，口腔的特定条件，如高温，低pH值和唾液的存在会影响水解速率。该研究检查了PCL和PLA的固体样品在磷酸盐缓冲盐水（PBS）和人工唾液（AS）中在37或42摄氏度的温度和pH值2或7.4下降解的特性。进行了许多测试，包括测量溶胀度、重量损失、分子量、差示扫描量热法和聚合物的热重分析，以及硬度和拉伸强度。此外，形貌和刚度的表面，使用原子力显微镜。已经注意到，在人工唾液中，聚合物降解的过程发生得稍微慢一些，并且温度和pH的影响不太明显。我们认为，吸附在聚合物表面上的来自人工唾液的猪胃粘蛋白层可能在观察到的差异中起关键作用;该层类似于口腔中的保护性粘蛋白涂层组织。
Polycaprolactone (PCL) and polylactide (PLA) are the two most common biodegradable polymers with potential use in oral applications. Both polymers undergo mainly slow hydrolytic degradation in the human body. However, specific conditions of the oral cavity, like elevated temperature, low pH, and presence of saliva affect the rate of hydrolysis. The study examined the properties of solid samples of PCL and PLA subjected to degradation in phosphate buffered saline (PBS) and artificial saliva (AS) at temperatures of 37 or 42 degrees C, and pH values 2 or 7.4. A number of tests were performed, including measurement of the degree of swelling, weight loss, molecular weight, differential scanning calorimetry, and thermogravimetry of polymers, as well as hardness and tensile strength. Additionally, topography and stiffness of surfaces using atomic force microscopy are presented. It has been noticed that in the artificial saliva, the processes of polymer degradation occur slightly more slowly, and the effects of temperature and pH are less pronounced. We believe that a layer of porcine gastric mucin from artificial saliva that adsorbed on the surface of polymers may have a key role in the observed differences; this layer resembles protective mucin coating tissues in the oral cavity.